Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics

Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics

Ten eleven translocation (Tet) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC and 5caC can be further excised by thymine-DNA glycosylase (Tdg). Here, we present a genome-wide approach, named methylation-assisted b...

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Bibliographic Details
Main Authors: Francesco Neri, Danny Incarnato, Anna Krepelova, Stefania Rapelli, Francesca Anselmi, Caterina Parlato, Claudio Medana, Federica Dal Bello, Salvatore Oliviero
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715000091

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http://www.sciencedirect.com/science/article/pii/S2211124715000091

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