In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase

In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase

Reduced levels of γ-aminobutyric acid (GABA) are cause of quite a many diseases, and it cannot be directly introduced into the body to enhance its level because of the blood–brain barrier. Thus the technique used for the purpose involves the inhibition of aminobutyrate transaminase (ABAT), the enzym...

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Bibliographic Details
Main Authors: Hira Iftikhar, Sidra Batool, Aakash Deep, Balasubramanian Narasimhan, Prabodh Chander Sharma, Manav Malhotra
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Arabian Journal of Chemistry
Subjects:
GABA
Aminobutyrate transaminase
ABAT
Homology modeling
Docking studies
GABA inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535213000762

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http://www.sciencedirect.com/science/article/pii/S1878535213000762

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