Predicting the origins of anti-blood group antibody specificity: A case study of the ABO A- and B-antigens

Predicting the origins of anti-blood group antibody specificity: A case study of the ABO A- and B-antigens

The ABO blood group system is the most important blood type system in human transfusion medicine. Here, we explore the specificity of antibody recognition towards ABO blood group antigens using computational modeling and biolayer interferometry. Automated docking and molecular dynamics (MD) simula...

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Bibliographic Details
Main Authors: Spandana eMakeneni, Ye eJi, David C Watson, N. Martin eYoung, Robert J Woods
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Immunology
Subjects:
Amber
Antibody Specificity
Blood Group Antigens
molecular docking
MD simulations
GLYCAM
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00397/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00397/full

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