CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development

CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development

Background and purpose: The endocannabinoid system became a promising target for osteoarthritis (OA) treatment. Functional selectivity of cannabinoids may increase their beneficial properties while reducing side effects. The aim of the present study was to evaluate the analgesic potential of two fun...

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Bibliographic Details
Main Authors: Jakub Mlost, Magdalena Kostrzewa, Małgorzata Borczyk, Marta Bryk, Jakub Chwastek, Michał Korostyński, Katarzyna Starowicz
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Osteoarthritis
CB2
Functional bias
MIA
Analgesia
Tolerance
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221000688

Internet

http://www.sciencedirect.com/science/article/pii/S0753332221000688

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