Suppression of osteogenic differentiation and mitochondrial function change in human periodontal ligament stem cells by melatonin at physiological levels

Suppression of osteogenic differentiation and mitochondrial function change in human periodontal ligament stem cells by melatonin at physiological levels

N-Acetyl-5-methoxytryptamine (melatonin, MT) at pharmacological concentrations promotes the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells; however, its role at physiological concentrations (1 pM–10 nM) remains unclear. We explored the effects of 1 pM–1 µM MT on the o...

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Bibliographic Details
Main Authors: Miaomiao Zheng, Fuping Zhang, Wenguo Fan, Liulin Jiang, Jingzhou Li, Shanshan Xie, Fang Huang, Hongwen He
Format: Article
Language:English
Published: PeerJ Inc. 2020-03-01
Series:PeerJ
Subjects:
Melatonin
Mitochondrial function
Mitochondrial dynamics
Osteogenic differentiation
Periodontal ligament stem cell
Online Access:https://peerj.com/articles/8663.pdf

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https://peerj.com/articles/8663.pdf

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