Increased Dendritic Branching of and Reduced δ-GABAA Receptor Expression on Parvalbumin-Positive Interneurons Increase Inhibitory Currents and Reduce Synaptic Plasticity at Puberty in Female Mouse CA1 Hippocampus

Increased Dendritic Branching of and Reduced δ-GABAA Receptor Expression on Parvalbumin-Positive Interneurons Increase Inhibitory Currents and Reduce Synaptic Plasticity at Puberty in Female Mouse CA1 Hippocampus

Parvalbumin positive (PV+) interneurons play a pivotal role in cognition and are known to be regulated developmentally and by ovarian hormones. The onset of puberty represents the end of a period of optimal learning when impairments in synaptic plasticity are observed in the CA1 hippocampus of femal...

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Bibliographic Details
Main Authors: Hui Shen, Lindsay Kenney, Sheryl S. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
parvalbumin
interneurons
CA1 hippocampus
puberty
delta
GABAA receptor
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00203/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00203/full

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