IL-15 Upregulates Telomerase Expression and Potently Increases Proliferative Capacity of NK, NKT-Like, and CD8 T Cells

IL-15 Upregulates Telomerase Expression and Potently Increases Proliferative Capacity of NK, NKT-Like, and CD8 T Cells

Interleukin-15 (IL-15) is a cytokine that has been shown to expand CD8 T cell and natural killer (NK) cell populations, and therefore has potential for potentiating adoptive immune cell therapy for cancer. Previously, IL-15 has been shown to induce proliferation of CD8 memory T cells through activat...

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Bibliographic Details
Main Authors: Fiona Watkinson, Sandeep Krishan Nayar, Aradhana Rani, Christina A. Sakellariou, Oussama Elhage, Efthymia Papaevangelou, Prokar Dasgupta, Christine Galustian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
interleukin-15
interleukin-2
telomerase
cell-signaling
adoptive cell therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.594620/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.594620/full

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