Germline <i>ERBB2</i>/<i>HER2</i> Coding Variants Are Associated with Increased Risk of Myeloproliferative Neoplasms

Germline <i>ERBB2</i>/<i>HER2</i> Coding Variants Are Associated with Increased Risk of Myeloproliferative Neoplasms

Familial cases of myeloproliferative neoplasms (MPN) are relatively common, yet few inherited risk factors have been identified. Exome sequencing of a kindred with a familial cancer syndrome characterized by both MPN and melanoma produced a germline variant in the <i>ERBB2/HER2</i> gene...

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Bibliographic Details
Main Authors: Evan M. Braunstein, Hang Chen, Felicia Juarez, Fanghan Yang, Lindsay Tao, Igor Makhlin, Donna M. Williams, Shruti Chaturvedi, Aparna Pallavajjala, Theodoros Karantanos, Renan Martin, Elizabeth Wohler, Nara Sobreira, Christopher D. Gocke, Alison R. Moliterno
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
familial cancer
myeloproliferative neoplasms
germline predisposition
Online Access:https://www.mdpi.com/2072-6694/13/13/3246

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https://www.mdpi.com/2072-6694/13/13/3246

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