The Antihypertensive Drug Telmisartan Protects Oligodendrocytes from Cholesterol Accumulation and Promotes Differentiation by a PPAR-γ-Mediated Mechanism

The Antihypertensive Drug Telmisartan Protects Oligodendrocytes from Cholesterol Accumulation and Promotes Differentiation by a PPAR-γ-Mediated Mechanism

Our previous studies have demonstrated that specific peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists play a fundamental role in oligodendrocyte progenitor (OP) differentiation, protecting them against oxidative and inflammatory damage. The antihypertensive drug Telmisartan (TLM) was s...

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Bibliographic Details
Main Authors: Antonietta Bernardo, Mariagiovanna Malara, Lucia Bertuccini, Chiara De Nuccio, Sergio Visentin, Luisa Minghetti
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
cholesterol accumulation
Niemann Pick type C disease
myelination
PPAR-γ
oligodendrocyte progenitors
drug repositioning
Online Access:https://www.mdpi.com/1422-0067/22/17/9434

Internet

https://www.mdpi.com/1422-0067/22/17/9434

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