Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity

Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity

Abstract Background The NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1β and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl pyruvate (EP) was previously shown to inhibit HMGB1 release and promote...

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Bibliographic Details
Main Authors: Sujun Li, Fang Liang, Kevin Kwan, Yiting Tang, Xiangyu Wang, Youzhou Tang, Jianhua Li, Huan Yang, Sangeeta S. Chavan, Haichao Wang, Ulf Andersson, Ben Lu, Kevin J. Tracey
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Molecular Medicine
Subjects:
Ethyl pyruvate
The NLRP3 inflammasomes
Mitochondrial damage
HMGB1
Interleukin-1beta
Online Access:http://link.springer.com/article/10.1186/s10020-018-0006-9

Internet

http://link.springer.com/article/10.1186/s10020-018-0006-9

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