Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

Abstract Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sorafenib is the first targeted drug for advanced HCC treatment. However, sorafenib re...

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Bibliographic Details
Main Authors: Jiao Feng, Jingjing Li, Liwei Wu, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai, Chuanyong Guo
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma
Aerobic glycolysis
HK2
PFK1
PKM2
HIF-1α
Online Access:http://link.springer.com/article/10.1186/s13046-020-01629-4

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http://link.springer.com/article/10.1186/s13046-020-01629-4

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