Autoantibodies are present before the clinical diagnosis of systemic sclerosis.

Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder associated with vascular dysfunction and fibrotic changes in the skin, vasculature and internal organs. Although serologic abnormalities are an important diagnostic tool for SSc, little is known about whether autoantibodies precede clin...

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Bibliographic Details
Main Authors: Peter D Burbelo, Sarah M Gordon, Meryl Waldman, Jess D Edison, Dustin J Little, Rodger S Stitt, Wayne T Bailey, James B Hughes, Stephen W Olson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0214202