Isolated limb perfusion with melphalan activates interferon-stimulated genes to induce tumor regression in patients with melanoma in-transit metastasis

Isolated limb perfusion with melphalan activates interferon-stimulated genes to induce tumor regression in patients with melanoma in-transit metastasis

Hyperthermic isolated limb perfusion (ILP) with high-dose melphalan is a treatment option for melanoma patients with metastasis confined to limbs (in-transit metastasis). The therapy entails a complete response (CR) rate of 50–70%. Cellular immunity is proposed to impact on the clinical efficacy of...

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Bibliographic Details
Main Authors: Junko Johansson, Roberta Kiffin, Ebru Aydin, Malin S. Nilsson, Kristoffer Hellstrand, Per Lindnér, Peter Naredi, Roger Olofsson Bagge, Anna Martner
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
melanoma
isolated limb perfusion
melphalan
isg
chemokines
t cell chemotaxis
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1684126

Internet

http://dx.doi.org/10.1080/2162402X.2019.1684126

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