Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice.

Zika virus (ZIKV) falls into two lineages: African (ZIKVAF) and Asian (ZIKVAS). These lineages have not been tested comprehensively in parallel for disease progression using an animal model system. Here, using the established type-I interferon receptor knockout (A129) mouse model, it is first demons...

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Bibliographic Details
Main Authors: Stuart D Dowall, Victoria A Graham, Emma Rayner, Laura Hunter, Barry Atkinson, Geoff Pearson, Mike Dennis, Roger Hewson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5510909?pdf=render