The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1

The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1

Abstract Background Our previous study has demonstrated that hepatocyte nuclear factor 1α (HNF1α) exerts potent therapeutic effects on hepatocellular carcinoma (HCC). However, the molecular mechanisms by which HNF1α reverses HCC malignancy need to be further elucidated. Methods lncRNA microarray was...

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Bibliographic Details
Main Authors: Chen-Hong Ding, Chuan Yin, Shi-Jie Chen, Liang-Zhi Wen, Kai Ding, Shu-Juan Lei, Jin-Pei Liu, Jian Wang, Kai-xian Chen, Hua-liang Jiang, Xin Zhang, Cheng Luo, Wei-Fen Xie
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
HNF1α
HNF1A-AS1
Hepatocellular carcinoma, SHP-1, phosphatase activity
Online Access:http://link.springer.com/article/10.1186/s12943-018-0813-1

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http://link.springer.com/article/10.1186/s12943-018-0813-1

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