Targeted Suppression of Chaperone-Mediated Autophagy by miR-320a Promotes α-Synuclein Aggregation

Targeted Suppression of Chaperone-Mediated Autophagy by miR-320a Promotes α-Synuclein Aggregation

Chaperone-mediated autophagy (CMA) is involved in wild-type α-synuclein degradation in Parkinson’s disease (PD), and LAMP2A and Hsc 70 have recently been indicated to be deregulated by microRNAs. To recognize the regularory role of miR-320a in CMA and the possible role in α-synuclein degradation, in...

Full description

Bibliographic Details
Main Authors: Guobin Li, Haiying Yang, Dezhang Zhu, Hui Huang, Guoyuan Liu, Peng Lun
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:International Journal of Molecular Sciences
Subjects:
miR-320a
α-synuclein aggregation
Hsc 70
chaperone-mediated autophagy
Parkinson disease
Online Access:http://www.mdpi.com/1422-0067/15/9/15845

Internet

http://www.mdpi.com/1422-0067/15/9/15845

Similar Items