Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile

Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile

Because lysine-specific demethylase 1 (LSD1) regulates the maintenance of cancer stem cell properties, small-molecule inhibitors of LSD1 are expected to be useful for the treatment of several cancers. Reversible inhibitors of LSD1 with submicromolar inhibitory potency have recently been reported, bu...

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Bibliographic Details
Main Authors: Hideaki Niwa, Shin Sato, Tomoko Hashimoto, Kenji Matsuno, Takashi Umehara
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
chromatin
epigenetics
histone demethylase
protein-inhibitor complex
crystal structure
Online Access:http://www.mdpi.com/1420-3049/23/7/1538

Internet

http://www.mdpi.com/1420-3049/23/7/1538

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