NLRP3 inflammasome of renal tubular epithelial cells induces kidney injury in acute hemolytic transfusion reactions

NLRP3 inflammasome of renal tubular epithelial cells induces kidney injury in acute hemolytic transfusion reactions

Abstract Background Blood transfusion, a common basic supporting therapy, can lead to acute hemolytic transfusion reaction (AHTR). AHTR poses a great risk to patients through kidney function damage in a short time. Previous reports found that heme from destroyed red blood cells impaired kidney funct...

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Bibliographic Details
Main Authors: Zhixin Liu, Yaozhen Chen, Bing Niu, Dandan Yin, Fan Feng, Shunli Gu, Qunxing An, Jinmei Xu, Ning An, Jing Zhang, Jing Yi, Wen Yin, Xiangyang Qin, Xingbin Hu
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Clinical and Translational Medicine
Subjects:
acute hemolytic transfusion reaction
heme
inhibitor
NLRP3 inflammasome
renal tubular epithelial cells
Online Access:https://doi.org/10.1002/ctm2.373

Internet

https://doi.org/10.1002/ctm2.373

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