ZEB1 protects skeletal muscle from damage and is required for its regeneration

ZEB1 protects skeletal muscle from damage and is required for its regeneration

Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiesc...

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Main Authors: Laura Siles, Chiara Ninfali, Marlies Cortés, Douglas S. Darling, Antonio Postigo
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08983-8
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spelling doaj-fba352a7d17a4354bb83f498fd54b6a62021-05-11T11:32:14ZengNature Publishing GroupNature Communications2041-17232019-03-0110111810.1038/s41467-019-08983-8ZEB1 protects skeletal muscle from damage and is required for its regenerationLaura Siles0Chiara Ninfali1Marlies Cortés2Douglas S. Darling3Antonio Postigo4Group of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPSGroup of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPSGroup of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPSCenter for Genetics and Molecular Medicine and Department of Immunology and Infectious Diseases, University of LouisvilleGroup of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPSFollowing muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiescence.https://doi.org/10.1038/s41467-019-08983-8
collection DOAJ
language English
format Article
sources DOAJ
author Laura Siles
Chiara Ninfali
Marlies Cortés
Douglas S. Darling
Antonio Postigo
spellingShingle Laura Siles
Chiara Ninfali
Marlies Cortés
Douglas S. Darling
Antonio Postigo
ZEB1 protects skeletal muscle from damage and is required for its regeneration
Nature Communications
author_facet Laura Siles
Chiara Ninfali
Marlies Cortés
Douglas S. Darling
Antonio Postigo
author_sort Laura Siles
title ZEB1 protects skeletal muscle from damage and is required for its regeneration
title_short ZEB1 protects skeletal muscle from damage and is required for its regeneration
title_full ZEB1 protects skeletal muscle from damage and is required for its regeneration
title_fullStr ZEB1 protects skeletal muscle from damage and is required for its regeneration
title_full_unstemmed ZEB1 protects skeletal muscle from damage and is required for its regeneration
title_sort zeb1 protects skeletal muscle from damage and is required for its regeneration
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiescence.
url https://doi.org/10.1038/s41467-019-08983-8
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AT chiaraninfali zeb1protectsskeletalmusclefromdamageandisrequiredforitsregeneration
AT marliescortes zeb1protectsskeletalmusclefromdamageandisrequiredforitsregeneration
AT douglassdarling zeb1protectsskeletalmusclefromdamageandisrequiredforitsregeneration
AT antoniopostigo zeb1protectsskeletalmusclefromdamageandisrequiredforitsregeneration
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