Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease

Abstract Background In Alzheimer’s Disease (AD), about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways. Among them, the Ras and Rab Interactor 3(RIN3) is a guanine nucleotide exchange factor (GEF) for the Rab5 small GTPase family a...

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Bibliographic Details
Main Authors: Ruinan Shen, Xiaobei Zhao, Lu He, Yongbo Ding, Wei Xu, Suzhen Lin, Savannah Fang, Wanlin Yang, Kijung Sung, Brian Spencer, Robert A. Rissman, Ming Lei, Jianqing Ding, Chengbiao Wu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease (AD)
AD risk factors
Endosomes
Trafficking
RIN3
BIN1
Online Access:http://link.springer.com/article/10.1186/s40035-020-00206-1

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http://link.springer.com/article/10.1186/s40035-020-00206-1

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