IL4I1 Accelerates the Expansion of Effector CD8+ T Cells at the Expense of Memory Precursors by Increasing the Threshold of T-Cell Activation

IL4I1 Accelerates the Expansion of Effector CD8+ T Cells at the Expense of Memory Precursors by Increasing the Threshold of T-Cell Activation

IL4I1 is an immunoregulatory enzyme that inhibits CD8 T-cell proliferation in vitro and in the tumoral context. Here, we dissected the effect of IL4I1 on CD8 T-cell priming by studying the differentiation of a transgenic CD8 T-cell clone and the endogenous repertoire in a mouse model of acute lympho...

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Bibliographic Details
Main Authors: Marie-Line Puiffe, Aurélie Dupont, Nouhoum Sako, Jérôme Gatineau, José L. Cohen, Denis Mestivier, Agnès Lebon, Armelle Prévost-Blondel, Flavia Castellano, Valérie Molinier-Frenkel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
immunosuppressive enzyme
T cell immune response
CD8 T cell
viral infection
T-cell activation
T-cell priming
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.600012/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.600012/full

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