IL4I1 Accelerates the Expansion of Effector CD8+ T Cells at the Expense of Memory Precursors by Increasing the Threshold of T-Cell Activation
IL4I1 is an immunoregulatory enzyme that inhibits CD8 T-cell proliferation in vitro and in the tumoral context. Here, we dissected the effect of IL4I1 on CD8 T-cell priming by studying the differentiation of a transgenic CD8 T-cell clone and the endogenous repertoire in a mouse model of acute lympho...
Main Authors: | Marie-Line Puiffe, Aurélie Dupont, Nouhoum Sako, Jérôme Gatineau, José L. Cohen, Denis Mestivier, Agnès Lebon, Armelle Prévost-Blondel, Flavia Castellano, Valérie Molinier-Frenkel |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-12-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.600012/full |
Similar Items
-
Editorial: Immunosuppressive Amino Acid Catabolizing Enzymes in Heallth and Disease
by: Flavia Castellano, et al.
Published: (2021-05-01) -
The IL4I1 Enzyme: A New Player in the Immunosuppressive Tumor Microenvironment
by: Valérie Molinier-Frenkel, et al.
Published: (2019-07-01) -
What role for AHR activation in IL4I1-mediated immunosuppression ?
by: Flavia Castellano, et al.
Published: (2021-01-01) -
An Overview of l-Amino Acid Oxidase Functions from Bacteria to Mammals: Focus on the Immunoregulatory Phenylalanine Oxidase IL4I1
by: Flavia Castellano, et al.
Published: (2017-12-01) -
Control of T-Cell Activation and Signaling by Amino-Acid Catabolizing Enzymes
by: Flavia Castellano, et al.
Published: (2020-12-01)