FOCUS: an alignment-free model to identify organisms in metagenomes using non-negative least squares

One of the major goals in metagenomics is to identify the organisms present in a microbial community from unannotated shotgun sequencing reads. Taxonomic profiling has valuable applications in biological and medical research, including disease diagnostics. Most currently available approaches do not...

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Bibliographic Details
Main Authors: Genivaldo Gueiros Z. Silva, Daniel A. Cuevas, Bas E. Dutilh, Robert A. Edwards
Format: Article
Language:English
Published: PeerJ Inc. 2014-06-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/425.pdf