Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and Urine

Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and Urine

The concentration of thiol and thioether metabolites in plasma has diagnostic value in genetic diseases of B-vitamin metabolism linked to methionine utilization. Among these, cysteine/cystine (Cys/CSSC) and glutathione/oxidized glutathione (GSH/GSSG) act as cellular redox buffers. A new LC-MS/MS met...

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Bibliographic Details
Main Authors: Sidney Behringer, Victoria Wingert, Victor Oria, Anke Schumann, Sarah Grünert, Artur Cieslar-Pobuda, Stefan Kölker, Ann-Kathrin Lederer, Donald W. Jacobsen, Judith Staerk, Oliver Schilling, Ute Spiekerkoetter, Luciana Hannibal
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Metabolites
Subjects:
methionine metabolism
homocysteine
glutathione
targeted metabolic profiling
mass spectrometry
thiol
biomarker
Online Access:https://www.mdpi.com/2218-1989/9/10/235

Internet

https://www.mdpi.com/2218-1989/9/10/235

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