Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing Brain

Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing Brain

Introduction: Preterm infants born before 28 weeks of gestation are at high risk of neurodevelopmental impairment in later life. Cerebral white and gray matter injury is associated with adverse outcomes. High oxygen levels, often unavoidable in neonatal intensive care, have been identified as one of...

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Bibliographic Details
Main Authors: Monia Vanessa Dewan, Meray Serdar, Yohan van de Looij, Mirjam Kowallick, Martin Hadamitzky, Stefanie Endesfelder, Joachim Fandrey, Stéphane V. Sizonenko, Josephine Herz, Ursula Felderhoff-Müser, Ivo Bendix
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neurology
Subjects:
erythropoietin
neuroprotection
preterm brain injury
white matter injury
hyperoxia
myelination
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00804/full

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https://www.frontiersin.org/article/10.3389/fneur.2020.00804/full

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