Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction

Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction

Host restriction of influenza A virus limits pandemic emergence. The viral RNA polymerase (vPol) is an essential enzyme that must adapt for avian viruses to replicate in humans. Species differences in host ANP32A dictate adaptation: human ANP32A lacks an uncharacterized 33 amino-acid insertion that...

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Bibliographic Details
Main Authors: Patricia Domingues, Benjamin G. Hale
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
influenza virus
host range
polymerase
restriction
SUMO
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311865

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717311865

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