Systems Biology-Based Analysis Indicates Global Transcriptional Impairment in Lead-Treated Human Neural Progenitor Cells

Systems Biology-Based Analysis Indicates Global Transcriptional Impairment in Lead-Treated Human Neural Progenitor Cells

Lead poisoning effects are wide and include nervous system impairment, peculiarly during development, leading to neural damage. Lead interaction with calcium and zinc-containing metalloproteins broadly affects cellular metabolism since these proteins are related to intracellular ion balance, activat...

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Bibliographic Details
Main Authors: Clovis F. Reis, Iara D. de Souza, Diego A. A. Morais, Raffael A. C. Oliveira, Danilo O. Imparato, Rita M. C. de Almeida, Rodrigo J. S. Dalmolin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Genetics
Subjects:
lead exposure
lead poisoning
transcriptogramer
RNA-seq
transcriptome analysis
network inference
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00791/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00791/full

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