Nav1.5 cardiac sodium channels, regulation and clinical implications
Voltage-gated sodium channels constitute a group of membrane proteins widely distributed thought the body. In the heart, there are at least six different isoforms, being the Nav1.5 the most abundant. The channel is composed of an α subunit that is formed by four domains of six segments each, and fou...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidad Nacional de Colombia
2014-10-01
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| Series: | Revista de la Facultad de Medicina |
| Subjects: | |
| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/44015 |
| Summary: | Voltage-gated sodium channels constitute a group of membrane
proteins widely distributed thought the body. In the heart, there
are at least six different isoforms, being the Nav1.5 the most
abundant. The channel is composed of an α subunit that is formed
by four domains of six segments each, and four much smaller β
subunits that provide stability and integrate other channels into
the α subunit. The function of the Nav1.5 channel is modulated
by intracellular cytoskeleton proteins, extracellular proteins,
calcium concentration, free radicals, and medications, among
other things. The study of the channel and its alterations has
grown thanks to its association with pathogenic conditions such
as Long QT syndrome, Brugada syndrome, atrial fibrillation,
arrhythmogenic ventricular dysplasia and complications during
ischemic processes. |
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| ISSN: | 0120-0011 2357-3848 |