Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells

Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells

Background/Aims: The ubiquitin proteasome system (UPS) is responsible for the degradation of most intracellular proteins, and proteasomal deubiquitinases (DUBs) have recently been highlighted as novel anticancer targets. It is well documented that copper complexes can inhibit UPS function through ta...

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Bibliographic Details
Main Authors: Xin Chen, Qianqian Yang, Jinghong Chen, Peiquan Zhang, Qingtian Huang, Xiaolan Zhang, Li Yang, Dacai Xu, Chong Zhao, Xuejun Wang, Jinbao Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Proteasome
Deubiquitinases
Silver complex
Apoptosis
Lung cancer
Online Access:https://www.karger.com/Article/FullText/493041

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https://www.karger.com/Article/FullText/493041

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