Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease

Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease

ABSTRACT: Pantothenate Kinase Associated Neurodegeneration (PKAN) is an autosomal recessive disorder with mutations in the pantothenate kinase 2 gene (PANK2), encoding an essential enzyme for Coenzyme A (CoA) biosynthesis. The molecular connection between defects in this enzyme and the neurodegenera...

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Bibliographic Details
Main Authors: Daniela Zizioli, Natascia Tiso, Adele Guglielmi, Claudia Saraceno, Giorgia Busolin, Roberta Giuliani, Deepak Khatri, Eugenio Monti, Giuseppe Borsani, Francesco Argenton, Dario Finazzi
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Neurobiology of Disease
Subjects:
Pank2
NBIA
Neurodegeneration
Coenzyme A
Pantethine
Morpholino
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300681

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http://www.sciencedirect.com/science/article/pii/S0969996115300681

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