Dual- versus single-agent HER2 inhibition and incidence of intracranial metastatic disease: a systematic review and meta-analysis

Abstract Observational studies have suggested that HER2 inhibition with trastuzumab may be associated with an increased incidence of intracranial metastatic disease (IMD) due to its ability to prolong survival. We hypothesized that prolonged survival associated with dual-agent HER2 inhibition may be...

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Bibliographic Details
Main Authors: Anders Wilder Erickson, Steven Habbous, Christianne Hoey, Katarzyna J. Jerzak, Sunit Das
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-021-00220-0