5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model

5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model

Serotonin receptors are potential neuroprotective agents in degenerative diseases of the central nervous system. The protective effects of serotonin receptor (5-HT1A) agonists on the survival and function of retinal ganglion cells (RGCs) by regulating the release of the presynaptic neurotransmitter...

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Bibliographic Details
Main Authors: Xujiao Zhou, Gang Li, Shenghai Zhang, Jihong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
5-HT1A receptor
OFF-type RGCs
glaucoma
glutamate release
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00167/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00167/full

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