Epigenetic reprogramming converts human Wharton’s jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators

Epigenetic reprogramming converts human Wharton’s jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators

Abstract Background Lineage commitment of mesenchymal stem cells (MSCs) to cardiac differentiation is controlled by transcription factors that are regulated by epigenetic events, mainly histone deacetylation and promoter DNA methylation. Here, we studied the differentiation of human Wharton’s jelly...

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Bibliographic Details
Main Authors: G. Bhuvanalakshmi, Frank Arfuso, Alan Prem Kumar, Arun Dharmarajan, Sudha Warrier
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Epigenetic modification
Cardiomyocytes
DNA methyltransferase
Histone deacetylase
Wharton’s jelly
Online Access:http://link.springer.com/article/10.1186/s13287-017-0638-7

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http://link.springer.com/article/10.1186/s13287-017-0638-7

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