Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism

Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism

Thymoquinone (TQ) has shown substantial evidence for its anticancer effects. Using human breast cancer cells, we evaluated the chemomodulatory effect of TQ on paclitaxel (PTX). TQ showed weak cytotoxic properties against MCF-7 and T47D breast cancer cells with IC<sub>50</sub> values of 6...

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Bibliographic Details
Main Authors: Hanan A. Bashmail, Aliaa A. Alamoudi, Abdulwahab Noorwali, Gehan A. Hegazy, Ghada M. Ajabnoor, Ahmed M. Al-Abd
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
paclitaxel
thymoquinone
apoptosis
autophagy
tumor-associated stem cells
Online Access:https://www.mdpi.com/1420-3049/25/2/426

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https://www.mdpi.com/1420-3049/25/2/426

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