T Cells Are Dominant Population in Human Abdominal Aortic Aneurysms and Their Infiltration in the Perivascular Tissue Correlates With Disease Severity

T Cells Are Dominant Population in Human Abdominal Aortic Aneurysms and Their Infiltration in the Perivascular Tissue Correlates With Disease Severity

Abdominal Aortic Aneurysm (AAA) is a major cause of cardiovascular mortality. Adverse changes in vascular phenotype act in concert with chronic inflammation to promote AAA progression. Perivascular adipose tissue (PVAT) helps maintain vascular homeostasis but when inflamed and dysfunctional, can als...

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Bibliographic Details
Main Authors: Agnieszka Sagan, Tomasz P. Mikolajczyk, Wojciech Mrowiecki, Neil MacRitchie, Kevin Daly, Alan Meldrum, Serena Migliarino, Christian Delles, Karol Urbanski, Grzegorz Filip, Boguslaw Kapelak, Pasquale Maffia, Rhian Touyz, Tomasz J. Guzik
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
abdominal aortic aneurysm
T cell
perivascular adipose tissue
inflammation
macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01979/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01979/full

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