Differential regulation of KCa2.1 (KCNN1) K+ channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure

Differential regulation of KCa2.1 (KCNN1) K+ channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure

Abstract Atrial fibrillation (AF) with concomitant heart failure (HF) poses a significant therapeutic challenge. Mechanism‐based approaches may optimize AF therapy. Small‐conductance, calcium‐activated K+ (KCa, KCNN) channels contribute to cardiac action potential repolarization. KCNN1 exhibits pred...

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Bibliographic Details
Main Authors: Ann‐Kathrin Rahm, Teresa Wieder, Dominik Gramlich, Mara Elena Müller, Maximilian N. Wunsch, Fadwa A. El Tahry, Tanja Heimberger, Steffi Sandke, Tanja Weis, Patrick Most, Hugo A. Katus, Dierk Thomas, Patrick Lugenbiel
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Physiological Reports
Subjects:
atrial fibrillation
electrophysiology
epigenetics
histone deacetylase
KCa channel
Online Access:https://doi.org/10.14814/phy2.14835

Internet

https://doi.org/10.14814/phy2.14835

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