TWIST1 associates with NF-κB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production

TWIST1 associates with NF-κB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production

<p>Abstract</p> <p>Background</p> <p>Metastasis is the primary cause of death for cancer patients. TWIST1, an evolutionarily conserved basic helix-loop-helix (bHLH) transcription factor, is a strong promoter of metastatic spread and its expression is elevated in many ad...

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Bibliographic Details
Main Authors: Li Shan, Kendall Stephen E, Raices Raquel, Finlay James, Covarrubias Maricela, Liu Zheng, Lowe Gina, Lin Yu-Huey, Teh Yuan, Leigh Victoria, Dhillon Simi, Flanagan Steven, Aboody Karen S, Glackin Carlotta A
Format: Article
Language:English
Published: BMC 2012-08-01
Series:BMC Biology
Subjects:
TWIST1
WR domain
RELA
NF-κB
IL8
Online Access:http://www.biomedcentral.com/1741-7007/10/73

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