Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

Abstract The P2Y12 receptor (P2Y12R) is a purinoceptor that is selectively expressed in microglia in the central nervous system. As a signature receptor, microglial P2Y12R mediates process chemotaxis towards ADP/ATP gradients and is engaged in several neurological diseases including chronic pain, st...

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Bibliographic Details
Main Authors: Jiyun Peng, Yong Liu, Anthony D. Umpierre, Manling Xie, Dai-Shi Tian, Jason R. Richardson, Long-Jun Wu
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Molecular Brain
Subjects:
Microglia
P2Y12 receptors
Hippocampus
Conditional knockout
Innate fear
Anxiety
Online Access:http://link.springer.com/article/10.1186/s13041-019-0492-x

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http://link.springer.com/article/10.1186/s13041-019-0492-x

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