Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers.

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers.

Adopting a systems approach, we devise a general workflow to define actionable subtypes in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four subtypes based on global gene expression patterns and ontologies. Three correspond to known subtypes (SCLC-A, SCLC-N, and S...

Full description

Bibliographic Details
Main Authors: David J Wooten, Sarah M Groves, Darren R Tyson, Qi Liu, Jing S Lim, Réka Albert, Carlos F Lopez, Julien Sage, Vito Quaranta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-10-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007343

Internet

https://doi.org/10.1371/journal.pcbi.1007343

Similar Items