Generate TALE/TALEN as Easily and Rapidly as Generating CRISPR

TALE has always had potential as a gene-editing and regulatory tool. However, with the advent of CRISPR/Cas9, an easier to use tool with the same function, TALE has recently been abandoned because of the time-consuming and low-efficiency process required for its construction. The off-target activity...

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Bibliographic Details
Main Authors: Shuyan Zhang, Huiting Chen, Jinke Wang
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S232905011930021X