Synthesis and DFT Calculations of Novel Vanillin-Chalcones and Their 3-Aryl-5-(4-(2-(dimethylamino)-ethoxy)-3-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde Derivatives as Antifungal Agents

Synthesis and DFT Calculations of Novel Vanillin-Chalcones and Their 3-Aryl-5-(4-(2-(dimethylamino)-ethoxy)-3-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde Derivatives as Antifungal Agents

Novel (E)-1-(aryl)-3-(4-(2-(dimethylamino)ethoxy)-3-methoxyphenyl) prop-2-en-1-ones 4 were synthesized by a Claisen-Schmidt reaction of 4-(2-(dimethylamino)ethoxy)-3-methoxy-benzaldehyde (2) with several acetophenone derivatives 3. Subsequently, cyclocondensation reactions of chalcones 4 with hydraz...

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Bibliographic Details
Main Authors: Luis Alberto Illicachi, Joel José Montalvo-Acosta, Alberto Insuasty, Jairo Quiroga, Rodrigo Abonia, Maximiliano Sortino, Susana Zacchino, Braulio Insuasty
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
antifungal activity
cyclocondensation reaction
chalcones
N-aryl-2-pyrazolines
DFT calculations
Online Access:https://www.mdpi.com/1420-3049/22/9/1476

Internet

https://www.mdpi.com/1420-3049/22/9/1476

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