A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters

A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters

Coenzyme A (CoA) is a ubiquitous cofactor present in every known organism. The thioesters of CoA are core intermediates in many metabolic processes, such as the citric acid cycle, fatty acid biosynthesis and secondary metabolism, including polyketide biosynthesis. Synthesis of CoA-thioesters is vita...

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Bibliographic Details
Main Authors: Dominik M. Peter, Bastian Vögeli, Niña Socorro Cortina, Tobias J. Erb
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Molecules
Subjects:
CoA-thioester
acylation
acyl-CoA dehydrogenases
enzyme promiscuity
secondary metabolites
polyketide synthase
natural product biosynthesis
biocatalysis
extender units
Online Access:http://www.mdpi.com/1420-3049/21/4/517

Internet

http://www.mdpi.com/1420-3049/21/4/517

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