Phosphoinositide-3-kinase is the primary mediator of phosphoinositide-dependent inhibition in mammalian olfactory receptor neurons

Phosphoinositide-3-kinase is the primary mediator of phosphoinositide-dependent inhibition in mammalian olfactory receptor neurons

Odorants inhibit as well as excite primary olfactory receptor neurons (ORNs) in many animal species. Growing evidence suggests that inhibition of mammalian ORNs is mediated by phosphoinositide (PI) signaling through activation of phosphoinositide 3-kinase (PI3K), and that canonical adenylyl cyclase...

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Bibliographic Details
Main Authors: Kirill eUkhanov, Elizabeth eCorey, Barry eAche
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Olfactory Receptor Neurons
phosphoinositide signaling
Single cell PCR
Odor inhibition
en face in vivo imaging
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00097/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00097/full

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