IL-33 Alarmin and Its Active Proinflammatory Fragments Are Released in Small Intestine in Celiac Disease

IL-33 Alarmin and Its Active Proinflammatory Fragments Are Released in Small Intestine in Celiac Disease

Initially described as Th2 promoter cytokine, more recently, IL-33 has been recognized as an alarmin, mainly in epithelial and endothelial cells. While localized in the nucleus acting as a gene regulator, it can be also released after injury, stress or inflammatory cell death. As proinflammatory sig...

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Bibliographic Details
Main Authors: Federico Perez, Carolina N. Ruera, Emanuel Miculan, Paula Carasi, Karen Dubois-Camacho, Laura Garbi, Luciana Guzman, Marcela A. Hermoso, Fernando G. Chirdo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
IL-33
ST2
celiac disease
alarmins
inflammation
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.581445/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.581445/full

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