Immunization with Toxoplasma gondii GRA17 Deletion Mutant Induces Partial Protection and Survival in Challenged Mice

Immunization with Toxoplasma gondii GRA17 Deletion Mutant Induces Partial Protection and Survival in Challenged Mice

Toxoplasmosis remains a world-threatening disease largely because of the lack of a fully effective vaccine. Here, we created a ΔGRA17 mutant by disrupting the virulence factor GRA17 using CRISPR-Cas9 method. Then, we tested whether ΔGRA17 tachyzoites can be used as a live-attenuated vaccine against...

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Bibliographic Details
Main Authors: Jin-Lei Wang, Hany M. Elsheikha, Wei-Ning Zhu, Kai Chen, Ting-Ting Li, Dong-Mei Yue, Xiao-Xuan Zhang, Si-Yang Huang, Xing-Quan Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
Toxoplasma gondii
immunization
live-attenuated vaccine
ΔGRA17
Th1/Th2 cytokines
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00730/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00730/full

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