Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of <i>Nedd4-2</i>

Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of <i>Nedd4-2</i>

Our previous study showed that in adult mice, conditional <i>Nedd4-2</i>-deficiency in club and alveolar epithelial type II (AE2) cells results in impaired mucociliary clearance, accumulation of <i>Muc5b</i> and progressive, terminal pulmonary fibrosis within 16 weeks. In the...

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Bibliographic Details
Main Authors: Theresa A. Engelmann, Lars Knudsen, Dominik H. W. Leitz, Julia Duerr, Michael F. Beers, Marcus A. Mall, Matthias Ochs
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Nedd4-2</i>
pulmonary fibrosis
regeneration
alveolar epithelium
alveolar epithelial type 2 cells
surfactant
Online Access:https://www.mdpi.com/1422-0067/22/14/7607

Internet

https://www.mdpi.com/1422-0067/22/14/7607

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