Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy

Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy

Although cytokine-based therapy is a promising tool to control the progression of esophageal cancer, low therapeutic responses largely compromise treatment efficacy through unidentified mechanisms. The goal of our study was to explore the roles of macrophage stimulating 1 (Mst1) and mitophagy in enh...

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Bibliographic Details
Main Authors: Jianpeng Zhang, Lin Sun, Weiqiang Li, Yanyu Wang, Xinzhen Li, Yang Liu
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
IL-24
Mst1
Mitochondrial stress
Mitophagy
ERK-Mfn2 pathway
Esophageal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219309497

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http://www.sciencedirect.com/science/article/pii/S0753332219309497

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