Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion

Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion

Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation. Here, we show that ICOSL is heavily downmodulated dur...

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Bibliographic Details
Main Authors: Guillem Angulo, Jelena Zeleznjak, Pablo Martínez-Vicente, Joan Puñet-Ortiz, Hartmut Hengel, Martin Messerle, Annette Oxenius, Stipan Jonjic, Astrid Krmpotić, Pablo Engel, Ana Angulo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
cytomegalovirus
herpesvirus
t-cell co-stimulation
icosl
cd275
viral immune evasion
Online Access:https://elifesciences.org/articles/59350

Internet

https://elifesciences.org/articles/59350

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