RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.

RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.

BACKGROUND: Telomeric 3' overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4 ligands have been designed to directly disrupt...

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Bibliographic Details
Main Authors: Sunil Lagah, I-Li Tan, Priya Radhakrishnan, Robert A Hirst, Jennifer H Ward, Chris O'Callaghan, Stuart J Smith, Malcolm F G Stevens, Richard G Grundy, Ruman Rahman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3893285?pdf=render

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http://europepmc.org/articles/PMC3893285?pdf=render

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