RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.
BACKGROUND: Telomeric 3' overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4 ligands have been designed to directly disrupt...
Main Authors: | Sunil Lagah, I-Li Tan, Priya Radhakrishnan, Robert A Hirst, Jennifer H Ward, Chris O'Callaghan, Stuart J Smith, Malcolm F G Stevens, Richard G Grundy, Ruman Rahman |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3893285?pdf=render |
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